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Aqua Tofana (also known as Acqua Toffana, Acquetta Perugina, and Aqua Tufania and Manna di San Nicola) was a strong poison created in Sicily around 1630 that was reputedly widely used in Naples, Perugia, and Rome, Italy. It has been associated with Giulia Tofana, or Tofania, a woman from Palermo, purportedly the leader of a ring of six poisoners in Rome, who sold Aqua Tofana to would-be widows.
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