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The Dicastery for the Doctrine of the Faith (DDF) is the oldest among the departments of the Roman Curia. Its seat is the Palace of the Holy Office in Rome. It was founded to defend the Catholic Church from heresy and is the body responsible for promulgating and defending Catholic doctrine.Formerly known as the Supreme Sacred Congregation of the Roman and Universal Inquisition (1542–1908); the Supreme Sacred Congregation of the Holy Office (1908–1965); and then until June 2022 the Congregation for the Doctrine of the Faith (CDF; Latin: Congregatio pro Doctrina Fidei). It is still informally known as the Holy Office (Latin: Sanctum Officium) in many Catholic countries.Founded by Pope Paul III on 21 July 1542, the sole objective of the dicastery is to "spread sound Catholic doctrine and defend those points of Christian tradition which seem in danger because of new and unacceptable doctrines."Its headquarters are at the Palace of the Holy Office, just outside Vatican City. The congregation employs an advisory board including cardinals, bishops, priests, lay theologians, and canon lawyers. The current Cardinal Prefect is Luis Ladaria Ferrer, who was appointed by Pope Francis for a five-year term starting 1 July 2017. On 1 July 2023, Francis named Argentine archbishop Víctor Manuel Fernández prefect as prefect, to take possession of the office in mid-September.

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