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Up Syndrome is a 2001 American documentary directed by Duane Graves. It was picked up for distribution by CineClix shortly after its world premiere at the 2001 Slamdance Film Festival in Park City, Utah, and made available in the US via Amazon Prime. Its director and subject, both lifelong friends, took home the National Media Award from the National Down Syndrome Congress in 2002. The film was selected to join the permanent archives of the United States Library of Congress in 2009.

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